Cestal Plus Dog 1 tab per 10 kg

Pharmacological properties:

Antitrematodal, antinematodal and anticestodal veterinary medicines — praziquantel, pyrantel embonate, fenbendazole.

Praziquantel, a pyrazinoisoquinoline derivative, is rapidly absorbed through the outer integument of tapeworms, causing damage and contraction.

Impaired membrane permeability results in paralysis of the parasites. Praziquantel is rapidly absorbed in the digestive tract.

Its peak plasma concentration is reached 1 - 2 hours after administration; it is rapidly metabolised and excreted as metabolites in the urine.

Pyrantel embonate is a tetrahydropyrimidine derivative that acts as a cholinergic antagonist, causing spastic paralysis of roundworms through depolarising neuromuscular blockade. Peak plasma concentration of pyrantel embonate is reached within 2 - 4 hours.

Pyrantel embonate is excreted from the body in faeces and urine within 24 hours.

Fenbendazole belongs to the benzimidazole group.

Soluble in formic acid.

Fenbendazole acts by disrupting glucose transport and microtubular function and reducing the synthesis of fumarate reductase in helminths.

This action causes paralysis and leads to the death of the helminths.

Inhibition of fumarate reductase synthesis reduces glycogen levels in the parasites' bodies. Fenbendazole inhibits the polymerisation of tubulin into microtubules, which disrupts the intracellular transport of nutrients and metabolites (adenosine triphosphate and glucose).

Composition:

1 tablet (780 ml) contains:

• Pyrantel embonate - 144 mg
• Praziquantel - 50 mg
• Fenbendazole - 200 mg

Excipients: lactose, wheat starch, povidone (K-90), talc, magnesium stearate, dried yeast, flavouring, purified water.

Indications:

A combined, highly effective product for the treatment and prevention of ascariasis, hookworm infection, cestodiasis and trichuriasis.

Low toxicity for warm-blooded animals, well tolerated by dogs; at the recommended doses it has no embryotoxic or teratogenic properties.

Thanks to the liver-flavoured additive, dogs eat the product readily.

Deworming of dogs infected with nematodes and cestodes: Toxocara canis, Toxascaris leonina; Ancylostoma caninum, Uncinaria stenocephala; Taenia species, Dipylidium caninum, Echinococcus species; Trichuris vulpis.

Administration and dosage:

Give the tablets directly or with food (with a piece of meat, sausage, etc.).

No prior fasting is required.

For prevention, the product should be given once every three months.

For treatment, a single dose is given. In case of heavy infestation, the treatment should be repeated after 14 days.

Orally at a dose of 1 tablet per 10 kg of the dog's body weight (equivalent to praziquantel - 5 mg/kg, pyrantel embonate - 14,4 mg/kg, fenbendazole - 20 mg/kg).

Puppies and small breed dogs:

• under 2 kg of body weight - 1/4 tablet
• 2 - 5 kg of body weight - 1/2 tablet
• 5 - 10 kg of body weight - 1 tablet

Medium-sized dogs:

• 10 - 20 kg of body weight - 2 tablets
• 20 - 30 kg of body weight - 3 tablets

Large breed dogs:

• 30 - 40 kg of body weight - 4 tablets
• 40 - 50 kg of body weight - 5 tablets

Contraindications:

Do not use in animals hypersensitive to the components, or in weakened and sick animals. The product can be used in puppies from 3 months of age.

Side effects:

Not established

Storage conditions:

Store in a dry, dark place at a temperature of 15 to 25°C, out of the reach of children and animals, away from food and feed.