Ceva Cestal Plus Dog tablets 1 x 8 tablets

Tablets for dogs Ceva Cestal Plus Dog Cestal Plus against worms 8 tablets pack

Pharmacological properties:

Anti-trematode, anti-nematode and anti-cestode veterinary drugs - praziquantel, pyrantel embonate, fenbendazole.

Praziquantel is a pyrazinoisoquinoline derivative that is rapidly absorbed through the outer membrane of tapeworms, resulting in its damage and contraction.

The consequence of the disruption of membrane permeability is paralysis of the parasites. Praziquantel is rapidly absorbed in the digestive tract.

Its highest concentration in blood plasma is reached within 1 - 2 hours after administration; it is quickly metabolized and excreted as metabolites in the urine.

Pyrantel embonate is a tetrahydropyrimidine derivative that acts as a cholinergic antagonist, causing spastic paralysis of roundworms through depolarizing neuromuscular blockade. The maximum concentration of pyrantel embonate in blood plasma is reached within 2 - 4 hours.

Pyrantel embonate is excreted from the body in feces and urine within 24 hours.

Fenbendazole belongs to the benzimidazole group.

Soluble in formic acid.

The mechanism of action of fenbendazole consists in disrupting glucose transport, impairing microtubular function, and reducing the activity of fumarate reductase synthesis in the body of helminths.

This action causes paralysis and leads to the death of helminths.

Inhibition of fumarate reductase synthesis leads to a decrease in glycogen levels in the body of parasites. Fenbendazole inhibits the polymerization of tubulin into microtubules, resulting in disruption of the intracellular transport of nutrients and metabolic substances (adenosine triphosphate and glucose).

Composition:

1 tablet (780 ml) contains:

• Pyrantel embonate - 144 mg
• Praziquantel - 50 mg
• Fenbendazole - 200 mg

Excipients: lactose, wheat starch, povidone (K-90), talc, magnesium stearate, dried yeast, flavoring, purified water.

Indications for use:

A combined, highly effective drug for the treatment and prevention of ascariasis, ancylostomiasis, cestodiasis and trichuriasis.

Low toxicity for warm-blooded animals, well tolerated by dogs; at recommended doses it has no embryotoxic or teratogenic properties.

Thanks to its liver-flavored additive, the drug is readily eaten by dogs.

Deworming of dogs affected by nematodes and cestodes: Toxocara canis, Toxascaris leonina; Ancylostoma caninum, Uncinaria stenocephala; Taenia species, Dipylidium caninum, Echinococcus species; Trichuris vulpis.

Method of application and dosage:

The tablets are given to animals forcibly or with food (with a piece of meat, sausage, etc.).

There is no need to observe a preliminary fasting diet.

For prevention, the drug should be given once every three months.

For treatment, it is administered once. In case of severe infestation, treatment should be repeated after 14 days.

Orally at a dose of 1 tablet per 10 kg of the dog's body weight (equivalent to praziquantel - 5 mg/kg, pyrantel embonate - 14,4 mg/kg, fenbendazole - 20 mg/kg).

Puppies and small breed dogs:

• less than 2 kg body weight - 1/4 tablet
• 2 - 5 kg body weight - 1/2 tablet
• 5 - 10 kg body weight - 1 tablet

Medium breed dogs:

• 10 - 20 kg body weight - 2 tablets
• 20 - 30 kg body weight - 3 tablets

Large breed dogs:

• 30 - 40 kg body weight - 4 tablets
• 40 - 50 kg body weight - 5 tablets

Contraindications:

Do not use in animals hypersensitive to the components of the drug, or in weakened or sick animals. The drug can be used in puppies from 3 months of age.

Side effects:

None established

Storage conditions:

Store in a dry, dark place at a temperature of 15 to 25°C, out of reach of children and animals, separately from food products and feed.