Boehringer Ingelheim Previcox 227 mg blister for canine osteoarthritis

Boehringer Ingelheim Previcox for the treatment of osteoarthritis in dogs, 227 mg

Boehringer Ingelheim Previcox (Boehringer Ingelheim Previcox).

Highly selective non-steroidal anti-inflammatory drug for dogs with a unique active ingredient firocoxib in tablet form.

The active ingredient contains firocoxib - 24% (depending on the dosage, 57 mg and 227 mg per tablet, respectively), as well as excipients: lactose monohydrate - 49.3%, microcrystalline cellulose - 15%, hydroxypropylcellulose - 3.0%, croscarmellose - 2.8%, colloidal silicon dioxide - 0.5%, flavoring and aromatic substances (flavor of smoked meat “Chartor Hickory smoke flavor” and caramel) - 5%, pigments - yellow and red iron oxides - 0.4%.

In appearance, the drug is a brown tablet, round in shape, convex, with a risk tablet on one side and an engraving “M and dosage”. Store the medicinal product in the manufacturer's sealed packaging, separately from food and feed, in a dry place, protected from direct sunlight, at a temperature of 0°C to 30°C.

The shelf life of the medicinal product, subject to storage conditions, is 4 years from the date of manufacture. The unused half of the tablet can be stored in the blister for no more than 7 days.

Pharmacological properties.

Previcox tablets 57 mg and 227 mg belong to the group of non-steroidal anti-inflammatory drugs. Firocoxib, which is part of the drug, is a selective inhibitor of cyclooxygenase-2 (COX-2), selectively disrupts the formation of prostaglandins involved in the formation of the inflammatory response, and suppresses the exudative and proliferative phases of inflammation. It acts predominantly at the site of inflammation and has virtually no effect on the production of prostaglandins that regulate renal blood flow and the integrity of the mucous membrane of the gastrointestinal tract. It has an analgesic, anti-inflammatory and antipyretic effect. Following oral administration to dogs at the recommended dose, firocoxib is rapidly absorbed, with maximum blood concentrations achieved within 1.25 hours. The half-life is 8 hours. Firocoxib is almost completely bound to blood proteins, metabolized in the liver, and excreted in bile through the intestines. Previcox tablets 57 mg and 227 mg in terms of the degree of impact on the body are classified as moderately hazardous substances (hazard class 3 according to GOST 12.1.007-76), in recommended doses they do not have a sensitizing, teratogenic or embryotoxic effect.

Application order.

Previcox tablets 57 mg and 227 mg are prescribed to dogs as an anti-inflammatory, analgesic and antipyretic agent in the treatment of osteoarthritis, as well as after orthopedic, dental and soft tissue operations. A contraindication for use is the animal’s increased individual sensitivity to the components of the drug (including a history of it). It is prohibited to use the drug in pregnant and lactating females, puppies under 10 weeks of age and dogs weighing less than 3 kg, as well as animals with gastrointestinal bleeding, blood diseases, hemorrhagic syndrome and severe renal and liver failure. Previcox tablets 57 mg and 227 mg are administered to dogs individually orally once a day at a dose of 5 mg firocoxib per 1 kg of animal weight. Previcox tablets 57 mg and 227 mg have an attractive aroma and taste, so they are readily eaten by dogs; if the drug is refused, it is fed with food. The duration of treatment for osteoarthritis depends on the condition of the animal and is determined by the attending veterinarian. Use of the drug for more than 90 days should be carried out under the regular supervision of a veterinarian. To relieve postoperative pain and inflammation during soft tissue operations, orthopedic and dental operations, the drug is used 2 hours before the start of the operation, and then, if necessary, 1 time per day for 2-3 days. In case of an overdose of the drug, the animal may experience excessive salivation, gastrointestinal upset, and a depressed state. No peculiarities of action were identified during the first use of the drug and when it was discontinued. Violations of the drug use regimen should be avoided, as this may lead to a decrease in its effectiveness. If you miss another dose of the drug, its use must be resumed in the prescribed dosage and according to the same regimen. When using the drug in accordance with these instructions, side effects and complications in animals, as a rule, are not observed. Previcox tablets 57 mg and 227 mg should not be used concomitantly with other non-steroidal anti-inflammatory drugs and glucocorticosteroids.

• The most selective COX-2 inhibitor, allowing for excellent results

• Safe for long-term use

• Fast-acting, within 15 minutes after the first dose

• Powerful pain relief 24 hours a day without “failure” in pain relief

• Steady increase in the degree of improvement of parameters during long-term treatment

• Leads to improvements noticeable to dog owners

• Higher level of improvement compared to NSAIDs with a predominant anti-inflammatory effect

• Provides global control of osteoarthritis with maximum satisfaction for veterinarians and dog owners.