Boehringer Ingelheim NexGard (Boehringer Ingelheim NexGard) a new drug to combat ectoparasites in dogs, dosage XL - for dogs weighing from 25 to 50 kg.
NEXGARD refers to insectoacaricidal drugs with systemic action.
Afoxolaner, which is part of the drug, is an insectoacaricide of the isoxazoline group. The mechanism of action of afoxolaner is to block GABA-dependent arthropod receptors, hyperexcite neurons, disrupt the transmission of nerve impulses, which leads to paralysis and death of parasites.
NEXGARDis active in relation to
fleas:Ctenocephalides felis, Ctenocephalides canis,
ixodidticks:Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Ixodes holocyclus, Haiaphysalis longicornis, Amblyomma americanum.
After oral administration of the drug, afoxolaner is easily absorbed from the gastrointestinal tract and reaches the systemic circulation, the maximum plasma concentration is observed 2-4 hours after administration. Afoxolaner is slowly metabolized and excreted from the body mainly in bile and slightly in urine. The half-life of afoxolaner is 14 days.
The effect of the drug on fleas begins 30 minutes after administration; a single use of the drug ensures the destruction of fleas and ticks on an animal within 6 and 48 hours, respectively; prevents re-infection for 4 weeks. The death of fleas occurs before laying eggs, which prevents contamination of premises with eggs and larvae.
Application
NEXGARD is prescribed to dogs for the treatment and prevention of infection with ticks (Dermacentor variabilis, Dermacentor reticulatus, Ixodes ricinus, Ixodes scapularis, Rhipicephalus sanguineus, Amblyomma americanum and Haiaphysalis longicornis) and fleas (Ctenocephalides felis and Ctenocephalides canis). The drug can be used as one of the remedies in the treatment of flea allergic dermatitis in dogs.
The drug should not be used by sick, weakened animals, puppies under 8 weeks of age and/or weighing less than 2 kg, as well as animals of other species.
Dosage
| Dog weight (kg) |
Tablet weight (g) |
Dose of active substance (mg/tablet) |
| 2-4 |
0.5 |
11.3 |
| 4.1-10 |
1.25 |
28.3 |
| 4.1-10 |
3.0 |
68.0 |
| 25.1-50 |
6.0 |
136.0 |
Repeated treatments during the season of greatest activity of ectoparasites are carried out monthly. When using the drug in dogs weighing more than 50 kg, a combination of tablets should be used at the rate of 2.5 mg of afoxolaner per 1 kg of weight. Breaking of tablets is not allowed.
NEXGARD has an attractive aroma and taste and, as a rule, is readily eaten by dogs; otherwise, the drug is fed mixed with food.
